Oral and Poster presentations

Here you can find Oral and Posters presentations.

Oral presentations

SESSION I: IMMUNOLOGY I Chair: P. Mastrantonio
		Rupnik, M.	OPENING
	INV1	Sansonetti, P.	LEARNING FROM PATHOGENS ORIGINAL STRATEGIES OF IMMUNOMANIPULATION
	O1	Heinrichs, J. H.	DESIGN, PRODUCTION AND PRE-CLINICAL EVALUATION OF A NOVEL TOXIN-BASED VACCINE FOR THE PREVENTION OF Clostridium difficile DISEASE
	O2	Jansen, K. U.	A NOVEL APPROACH TO A C. difficile TOXOID VACCINE: IMMUNOGENICITY AND PRECLINICAL EFFICACY
	O3	Anosova, N.	TOXIN A AND TOXIN B SPECIFIC SYSTEMIC ANTIBODY LEVELS CORRELATE WITH PROTECTION AGAINST C. difficile ASSOCIATED DISEASE IN HAMSTERS
SESSION II: SPORULATION AND GERMINATION Chair: N. Minton
	INV2	Henriques, A. O.	SPORE DEVELOPMENT IN RELATION TO PATHOGENESIS IN Clostridium difficile
	O4	Dembek, M.	TRANSCRIPTIONAL ANALYSIS OF GERMINATON IN Clostridium difficile 630 ENDOSPORES
	O5	Sorg, J. A.	IDENTIFYING FACTORS THAT INFLUENCE Clostridium difficile SPORE GERMINATION
	O6	Cutting, S. M.	THE SPORE COATS OF C. difficile
SESSION III: PATHOGENESIS AND VIRULENCE FACTORS Chair: I. Poxton
	INV3	Lacy, B.	STRUCTURES AND FUNCTIONS OF Clostridium difficile TcdA and TcdB
	O7	Michell, S.	THE ROLE OF LIPOPROTEINS IN Clostridium difficile ADHERENCE
	O8	Papatheodorou, P.	IDENTIFICATION OF THE HOST CELL RECEPTOR OF Clostridium difficile BINARY TOXIN CDT
	O9	Pich, A.	IMPACT OF CLOSTRIDIAL GLUCOSYLATING TOXINS ON THE PROTEOME OF COLONOCYTES
SESSION IV: IMMUNOLOGY II Chair: D. Gerding
	O10	Staelens, D.	IN VITRO AND IN VIVO CHARACTERIZATION OF NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST Clostridium difficile TOXINS A AND B
	O11	Songane, M.	MECHANISM(S) INVOLVED IN Clostridium difficile-MEDIATED INFLAMMASOME ACTIVATION
	O12	Solomon, K.	HOST INFLAMMATORY AND IMMUNE RESPONSE TO Clostridium difficile INFECTION: ROLE OF BACTERIAL CYTOTOXIN TITRE AND RELATIONSHIP WITH MORTALITY
	O13	Kansau, I.	FLAGELLA AND FLAGELLIN OF C. difficile 027 HYPERVIRULENT STRAIN ACTIVATE NF-κB AND ELICIT IL-8 PRODUCTION IN EPITHELIAL TLR-5-EXPRESSING CELL LINE
SESSION V: COMPARATIVE GENOMICS AND GENETICS Chair: S. Weese
	INV4	Dingle, K.	NOVEL INSIGHTS INTO C. difficile BIOLOGY AND EVOLUTION REVEALED BY WHOLE GENOME SEQUENCING
	O14	Minton, N. P.	WHAT'S A SNP BETWEEN FRIENDS?
	O15	Buckley, A.	WHAT'S LOV GOT TO DO WITH IT?
	O16	Soutourina, O.	EXPLORING sRNAs IN Clostridium difficile BY BIOINFORMATICS AND DEEP-SEQUENCING
SESSION VI: PHYSIOLOGY Chair: B. Dupuy
	INV5	Sonenshein, A. L.	METABOLIC CONTROL OF VIRULENCE IN Clostridium difficile
	017	Williams, R.	THE CONJUGATIVE TRANSPOSON TN5397 INSERTS INTO SPECIFIC SITES IN THE Clostridium difficile R20291 GENOME RESULTING IN SEVERE ATTENUATION OF VIRULENCE IN THE HAMSTER MODEL
	O18	Cartman, S. T.	IS TcdC REALLY A NEGATIVE REGULATOR OF TOXIN PRODUCTION IN Clostridium difficile?
	O19	Shaw, H. A.	INSIGHTS INTO SORTASE IN Clostridium difficile
SESSION VII: DIAGNOSTICS/CLINICAL ASPECT/INFECTION CONTROL I Chair: T. Louie
	INV6	Donskey, C.	INFECTION CONTROL OF Clostridium difficile: WHY ARE WE FAILING AND WHICH SPECIAL APPROACHES COULD HELP US SUCCEED?
	O20	Gupta, S. B.	A LARGE PROSPECTIVE NORTH AMERICAN EPIDEMIOLOGIC STUDY OF HOSPITAL-ASSOCIATED Clostridium difficile COLONIZATION & INFECTION
	O21	Tenover, F. C.	STRAIN TYPES AND RESISTANCE PATTERNS OF Clostridium difficile ISOLATES FROM UNITED STATES HOSPITALS
	O22	Khanafer, N.	HIGH MORTALITY RATE IN ONE YEAR COHORT STUDY AMONG PATIENTS WITH Clostridium difficile INFECTION (CDI) IN A LARGE TERTIARY HOSPITAL
SESSION VIII: DIAGNOSTICS/CLINICAL ASPECT/INFECTION CONTROL II Chair: A. Collignon
	INV7	Carroll, K.	CLINICAL IMPACT OF MOLECULAR TESTING FOR C. difficile DIAGNOSIS: THERE’S GOOD NEWS AND BAD!
	INV8	Ross, P.	PROBIOTICS, BACTERIOCINS AND BACTERIOPHAGE FOR LIMITING C. difficile INFECTION
	O23	Crowther, G. S.	VALIDATION OF A TRIPLE STAGE IN VITRO HUMAN GUT MODEL TO STUDY THE BIOFILM MODEL OF GROWTH OF C. difficile AND THE INDIGENOUS GUT
*SESSION IX: ROUND TABLE ON C. difficile* TYPING Chair: T. Riley and M. Rupnik**
	INV9	Kuijper, E.	DIAGNOSTICS AND TYPING OF Clostridium difficile INFECTIONS IN EUROPE
	INV10	Wilcox, M.	INCREASE USE OF RIBOTYPING - BUT WHERE NEXT?
	INV11	Indra, A.	ADVANTAGES AND DISADVANTAGES OF WEB BASED SYSTEMS TO IDENTIFY DNA PROFILES
	INV12	Mulvey, M.	THE CANADIAN EXPERIENCE WITH MOLECULAR TYPING METHODS FOR C. difficile: PFGE, PCR RIBOTYPING AND GENOME SEQUENCING
SESSION X: VETERINARY Chair: M. Rupnik
	O24	Riley, T. V.	AN OUTBREAK OF COMMUNITY-ACQUIRED Clostridium difficile INFECTION IN AUSTRALIA, 2011-12
	O25	Knight, D. R.	Clostridium difficile FROM AUSTRALIAN CATTLE - ALL WILL BE RE(VEAL)ED!
	O26	Keessen, E. C.	Clostridium 078 IN PIGS, A THREAT FOR FARMERS, THEIR RELATIVES AND EMPLOYEES
	O27	Weese, J. S.	EFFECT OF OXYTETRACYCLINE ON Clostridium difficile COLONIZATION AND THE FECAL MICROBIOME OF VEAL CALVES

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List of poster presentations

Poster number	First author	Title
P1	Gebhart, D.	Diffocins: novel, high-molecular weight bacteriocins highly specific for Clostridium difficile
P2	Ivarsson, M.	Alternatives to antibiotics for the treatment of Clostridium difficile infection
P3	Leuzzi, R.	Functional screening of TcdA and TcdB recombinant fragments as vaccine candidates against Clostridium difficile
P4	Miyajima, F.	The IL8 -251 SNP (rs4073) and other common candidate polymorphisms are not associated with Clostridium difficile Infection (CDI) in a prospective cohort
P5	Péchiné, S.	Impact of the immunization with the heat shock protein GroEL on Clostridium difficile intestinal colonization
P6	Pedneault, L.	Clostridium difficile anti-toxin A and B neutralization antibody titers and carriage in healthy adult volunteers aged 18 to 85 years
P7	Quemeneur, L.	Aluminum hydroxide adjuvant significantly increases immunogenicity and efficacy of a candidate bivalent toxoid vaccine in preclinical hamster challenge model
P8	Spencer, J.	Evaluation of the protective immunity induced by recombinant fragments from toxin A and B from Clostridium difficile in the hamster model
P9	Spencer, J.	Protective efficacy induced by recombinant Clostridium difficile toxin fragments
P10	Sun, X.	Essential involvement of TNF-α in Clostridium difficile infection
P11	Cafardi, V.	Identification and functional characterization of surface and secreted proteins of Clostridium difficile
P12	Dawson, L. F.	Production of biofilms by Clostridium difficile is affected by Spo0A
P13	Faulds-Pain, A.	Investigating the post-translational modification of the Clostridium difficile flagellin
P14	Gerhard, R.	Experimental strategies to combat cytoxic effects of TcdA and TcdB
P15	Kuehne, S. A.	Are both toxins A and B important in Clostridium difficile infection?
P16	Lima, B. B.	Clostridium difficile toxin A attenuates Wnt/beta-catenin signaling in intestinal epithelial cells
P17	Olling, A.	Cellular uptake of Clostridium difficile toxin A
P18	Pereira, F.	A protein required for efficient host colonization by Clostridium difficile is an abundant component of the spore surface layers
P19	Salgado, P. S.	Structural studies of the Clostridium difficile S-layer
P20	Seager, Z.	Investigation of potential colonisation factors in a mouse model of Clostridium difficile infection
P21	Spigaglia, P.	Clostridium difficile S layer variability and role in adherence to epithelial cells and intestinal colonization
P22	Tulli, L.	Characterization of a novel collagen binding protein of Clostridium difficile
P23	Walter, B.	Atypical cytophatic activity caused by Clostridium difficile A- B- CDT- strains
P24	Williams, R.	Characterisation of the prophage of Clostridium difficile 12727
P25	Heeg, D.	Spores of Clostridium difficile clinical isolates exhibit heterogeneous germination properties
P26	Kõljalg, S.	Population dynamics and sporulation of quinolone resistant and sensitive Clostridium difficile strains in different environmental conditions
P27	Saujet, L.	The regulatory cascade of sporulation in Clostridium difficile
P28	Ammam, F.	Clostridium difficile is surprisingly not resistant to vancomycin
P29	Ammam, F.	Functional analysis of the putative vancomycin resistance gene cluster (vanG-like) of Clostridium difficile
P30	Biazzo, M.	Diversity of cwp loci in clinical isolates of Clostridium difficile
P31	Bollard, N.	Characterization of Phosphotransferase Systems (PTS) in Clostridium difficile
P32	Chapet?n Montes, D.	Expression and maturation process of the Clostridium difficile protease Cwp84 could be influenced by environmental conditions
P33	Chong, P.	Proteomic analysis of a NAP1 Clostridium difficile clinical isolate with reduced susceptibility to metronidazole
P34	Collery, M. M.	Splitting the difference: the role of SNPs in the virulence of different strains of Clostridium difficile
P35	Dembek, M.	Clostridium difficile cell wall protein CwpV undergoes enzyme-independent intramolecular autoproteolysis
P36	Donahue, E.H.	Investigating the roles of the cell wall anchoring sortase enzyme and sorted proteins in Clostridium difficile
P37	Jabbari, S.	Mathematical modelling of the gene regulation network governing toxin production by Clostridium difficile
P38	Kirby, J. M.	A Clostridium difficile surface-located cysteine protease Cwp84 mutant displays decreased cell integrity and alteration of autolysin transcription
P39	Kuehne, S. A.	Analysing the growth characteristics, spore germination and outgrowth of Clostridium difficile clinical isolates challenged with fidaxomicin
P40	Mac Aogáin, M.	Investigation of QRDR-independent fluoroquinolone resistance in Irish Clostridium difficile isolates
P41	Mascio, C.	CB-183,315 demonstrates low in vitro frequency of spontaneous or multistep resistance in Clostridium difficile, Enterococcus faecalis and E. faecium
P42	Metcalf, D.	The effect of antimicrobials on expression of Clostridium difficile toxin B and binary toxin genes in vitro
P43	Moura, I.	In vitro susceptibility to metronidazole in different C. difficile PCR-ribotypes
P44	Negri, A.	Expression and display of FliD of Clostridium difficile on the surface of Bacillus subtilis spores
P45	Nimitray, J.	Genome-wide identification of small RNAs in Clostridium difficile
P46	Pecavar, V.	Clustered regularly interspaced short palindromic repeats (CRISPR) in Clostridium difficile
P47	Peltier, J.	Characterization of two major autolysins in Clostridium difficile
P48	Peltier, J.	Clostridium difficile has an original peptidoglycan structure with high level of N-acetylglucosamine deacetylation and mainly 3-3 cross-links
P49	Rosenbusch, K.	DNA binding by the master regulator of sporulation, Spo0A, of Clostridium difficile 630Δerm
P50	St-Pierre, É.	Inactivation of chemotaxis-associated genes increases flagellar motility in Clostridium difficile
P51	Van Eijk, E.	Identification and characterization of the replication machinery of Clostridium difficile
P52	Willing, S.	C. difficile cell wall protein anchoring
P53	Elliott, B.	Australia — home of Clostridium difficile clade 5?
P54	El Meouche, I.	The SigmaD factor controls the expression of flagella and toxins A and B in Clostridium difficile
P55	Kelly, M. L.	Toxin expression by Clostridium difficile is not entirely dependent on TcdR
P56	Van Leeuwen, H. C.	Clostridium difficile TcdC binds quadruplex DNA structures
P57	Wasels, F.	Behaviour of CTnCD11-like elements in Clostridium difficile
P58	Wasels, F.	Tn5398 from Clostridium difficile 630: new insights in mechanism of transfer, biological burden and expression of erm(B)
P59	Chilton, C.H.	Lactobacillus casei affects Clostridium difficile toxin detection in-vitro
P60	Daigneault, M.	A novel ecosystem therapeutic for the treatment of Clostridium difficile infections
P61	Miezeiewski, M.	Analysis of the microbiota of Syrian hamsters following clindamycin treatment and impact on Clostridium difficile susceptibility
P62	Rousseau, C.	Gut microbiota associated with Clostridium difficile colonization in infants investigated by pyrosequencing
P63	Bahadur, T.	Identification of Clostridium difficile infection in antibiotic associated diarrhea patients in Indian population
P64	Belanger, J.	Retrospective analysis of human biotherapy treatment for Clostridium difficile
P65	Benea, Ş.	Clostridium difficile infections hospitalized in Romanian Institute of Infectious Diseases during the first three months of 2012
P66	Butt, E.	Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection
P67	Faires, M.C.	Clostridium difficile contamination in the medical and surgical wards of a community hospital
P68	Hell, M.	Oral multispecies probiotic as adjunctive therapy for Clostridium difficile Infection: case series involving 10 patients (5 of them with recurrent CDI)
P69	Hell, M.	Effectiveness of a new surface disinfecting concept for reducing the risk of nosocomial Clostrium difficile infection
P70	Kato, H.	Bacteremia and splenic abscess due to Clostridium difficile without intestinal infections: a case report
P71	Kullin, B.	Clostridium difficile in a South African hospital setting: incidence and antibiotic resistance
P72	Tagashira, Y.	Two cases of fulminant colitis due to binary toxin-positive Clostridium difficile, which was neither PCR ribotype 027 nor type 078
P73	Taori, S.K.	Prospective analysis of Clostridium difficile cases in Scotland with emphasis on sporadic and outbreak strains of ribotype 078
P74	Trajkovska-Dokic, E.	Prevalence of Clostridium difficile in patients with antibiotic-associated diarrhoea and pseudomembranous colitis
P75	Avesani, V.	Trends in Clostridium difficile ribotype epidemiology in Belgium 2009-2011
P76	Banks, A.	Emergence of Clostridium difficile ribotype 078 in Scotland
P77	Beigot Glaser, S.	The variability of Clostridium difficile ribotypes isolated from a single wastewater treatment plant over a six month period
P78	Broukhanski, G.	The best typing method for investigation of C. difficile outbreaks: ribotyping, MLVA, MMLVA, eMLVA or riboMMLVA?
P79	Janezic, S.	Comparison of different primer pairs and electrophoresis platforms for Clostridium difficile PCR-ribotyping
P80	Jovanović, M.	Clostridium difficile at the Clinical Center of Serbia- spread over surgical and medical clinics
P81	Romano, V.	Occurrence and genotypic characterization of Clostridium difficile in food, animals and the environment in Italy and Switzerland
P82	Terhes, G.	Prevalence of gastrointestinal disease and clinical features of Clostridium difficile- associated infections: results of a retrospective study, 200-201 in a university hospital in Hungary
P83	Terhes, G.	Changes in the epidemiology and antibiotic susceptibility pattern of nosocomial and community-acquired Clostridium difficile in Hungary
P84	Torpdahl, M.	Tandem repeat sequence typing (TRST) as a replacement for PCR ribotyping in routine surveillance of Clostridium difficile
P85	Carson, K.	Isolation of Clostridium difficile from faecal specimens – a comparison of chromid C. difficile agar and cycloserine cefoxitin fructose agar containing taurocholoate
P86	Dobreva, E.	Implementation of molecular methods for identification, detection of toxin encoding genes and typing in Clostridium difficile
P87	Foster, N. F.	Analytical sensitivity of the BD GeneOhm™ Cdiff assay, the Meridian illumigene® C. difficile and the Cepheid Xpert® C. difficile for the detection of Clostridium difficile spores
P88	Kim, H.	Comparison of sensitivity of enzyme immunoassay for toxin A/B and distribution of PCR ribotypes in South Korea
P89	Knetsch, W.	Novel multiplex RT-PCR for the detection of lineage specific Clostridium difficile strains
P90	Koppler, T.	Development of a rapid Point-of-Care test system for the detection of toxigenic Clostridium difficile infections
P91	Lemire, A.	Characterization of three new toxinotypes of Clostridium difficile
P92	Metcalf, D.	Evaluation of commercial kits for extraction of DNA and RNA from Clostridium difficile
P93	Murabata, M.	Evaluation of culture media for Clostridium difficile isolation from environmental surfaces
P94	Narender, K.	Development, optimization and qualification of a sensitive high throughput cell-based neutralizing antibody assay for Clostridium difficile toxin A and B
P95	Senoh, M.	Rapid detection method of live Clostridium difficile
P96	Shin, B.	Effectiveness of C. difficile chrome agar for rapid diagnosis of C. difficile infection
P97	Thanki, A.	The development of a rapid-phage based biosensor for the identification of Clostridium difficile
P98	Van Broeck, J.	Evaluation of a chromogenic medium for the isolation of Clostridium difficile from stool samples using an automated inoculation system
P99	Eckert, C.	Detection of glutamate dehydrogenase in stool samples: evaluation of the IMMUNOQUICK C. DIFFICILE GDH ASSAY (Pro-Lab)
P100	Eckert, C.	Evaluation of VIDAS® Clostridium difficile Toxin A&B on colonies
P101	Eckert, C.	Isolation of Clostridium difficile in 24 hours with chrom-ID® C. difficile agar, a new chromogenic medium
P102	Eckert, C.	Contamination of ready-to-eat raw vegetables with Clostridium difficile, France
P103	Avbersek, J.	Clostridium difficile in goats and sheep in Slovenia
P104	Avbersek, J.	Detection of Clostridium difficile in animals: comparison of LightCycler and Taq-Man real-time PCR with the culture method
P105	Blanco, J.L.	Is Clostridium difficile prevalence in animals underestimated?
P106	Blanco, J.L.	Zero prevalence of Clostridium difficile in canary birds under antibiotic treatment
P107	Blanco, J.L.	Isolation of Clostridium difficile from puppies: a longitudinal study
P108	Blanco, J.L.	High recovery rate of Clostridium difficile PCR ribotype 078 in Iberian free-range pigs
P109	Drigo, I.	Clostridium difficile isolated from rabbits in Italian commercial farms
P110	Drigo, I.	Molecular characterization of Clostridium difficile isolated from pigs and humans in North-Eastern Italy
P111	Mentula, S.	Matching Clostridium difficile isolates in piglets and humans in Ostrobothnia area in Finland
P112	Niwa, H.	Isolation of PCR ribotype 078 Clostridium difficile from five cases of fulminant colitis in Thoroughbred racehorses
P113	Pirs, T.	Antimicrobial susceptibility testing of animal and human isolates of Clostridium difficile by broth microdilution
P114	Pirs, T.	Clostridium difficile in poultry production: detection and characterisation
P115	Richa, S.	Surveillance of Clostridium difficile in retail chicken: it’s antimicrobial and molecular characterization
P116	Rodriguez, C.	Clostridium difficile in intestinal contents and on carcasses of pigs and cattle at slaughterhouse in Belgium
P117	Squire, M.	A novel molecular type of Clostridium difficile in neonatal pigs in Australia lacks tcdA and tcdC but causes greater morbidity than 078 strains
P118	Zidaric, V.	Clostridium difficile in meat products, eggs and vegetables in Slovenia
P119	Zidaric, V.	International Clostridium difficile animal strain collection
P120	Škraban, J.	Different composition patterns of microbiota in C. difficile colonised and non - colonised humans and animals

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